3-Deazaadenosine-induced disorganization of macrophage microfilaments.
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of the antiviral agent carbocyclic 3-deazaadenosine.
The pharmacokinetics of carbocyclic 3-deazaadenosine (Cc3Ado), a competitive inhibitor of S-adenosyl-L-homocysteine hydrolase and novel antiviral agent, was investigated in female BALB/c mice. Mice were dosed either orally or intravenously with a single dose of 10 mg/kg (10 microCi [3H]Cc3Ado), and blood and tissue samples were taken at selected intervals for 24 hr. The plasma concentration vs....
متن کاملInhibition of murine erythroleukemia cell differentiation by 3-deazaadenosine.
Recent studies have demonstrated that 5'-methylthioadenosine, an inhibitor of S-adenosylhomocysteine (AdoHcy) hydrolase, blocks induction of murine erythroleukemia cell (MEL) differentiation. The nucleoside analogue 3-deazaadenosine (c3Ado) is both an efficient substrate and a potent inhibitor of AdoHcy hydrolase. The present study was undertaken to determine whether c3Ado would similarly inhib...
متن کامل3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice.
Chronic hyperhomocysteinemia (HHcy) is an important factor in development of arterial hypertension. HHcy is associated with activation of matrix metalloproteinases (MMPs); however, it is unclear whether HHcy-dependent extracellular matrix (ECM) accumulation plays a role in arterial hypertrophy and hypertension. We tested the hypothesis that in HHcy the mechanism of arterial hypertension involve...
متن کاملEffects of temperature on stability of blood homocysteine in collection tubes containing 3-deazaadenosine.
BACKGROUND The accuracy of homocysteine (Hcy) results is currently compromised by the requirement to separate the plasma within 1 h of sample collection. We studied the effect of temperature on the stability of plasma Hcy over a 72-h time course in blood collected into evacuated tubes containing either EDTA alone or both EDTA and 3-deazaadenosine (3DA). METHODS We recruited 100 volunteers, in...
متن کاملCystathionine- -synthase gene transfer and 3-deazaadenosine ameliorate inflammatory response in endothelial cells
Sen U, Tyagi N, Kumar M, Moshal KS, Rodriguez WE, Tyagi SC. Cystathionine-synthase gene transfer and 3-deazaadenosine ameliorate inflammatory response in endothelial cells. Am J Physiol Cell Physiol 293: C1779–C1787, 2007. First published September 13, 2007; doi:10.1152/ajpcell.00207.2007.—Although elevated levels of homocysteine (Hcy) known as hyperhomocysteinemia (HHcy) are associated with in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1985
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.82.12.4060